Msx homeobox gene family and craniofacial development
نویسندگان
چکیده
منابع مشابه
The homeobox gene Msx in development and transdifferentiation of jellyfish striated muscle.
Bilaterian Msx homeobox genes are generally expressed in areas of cell proliferation and in association with multipotent progenitor cells. Likewise, jellyfish Msx is expressed in progenitor cells of the developing entocodon, a cell layer giving rise to the striated and smooth muscles of the medusa. However, in contrast to the bilaterian homologs, Msx gene expression is maintained at high levels...
متن کاملThe evolution of Msx gene function: Expression and regulation of a sea urchin Msx class homeobox gene
Msx- class homeobox genes, characterized by a distinct and highly conserved homeodomain, have been identified in a wide variety of metazoans from vertebrates to coelenterates. Although there is evidence that they participate in inductive tissue interactions that underlie vertebrate organogenesis, including those that pattern the neural crest, there is little information about their function in ...
متن کاملSHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.
Deletion of the SHOX region on the human sex chromosomes has been shown to result in idiopathic short stature and proposed to play a role in the short stature associated with Turner syndrome. We have identified a human paired-related homeobox gene, SHOT, by virtue of its homology to the human SHOX and mouse OG-12 genes. Two different isoforms were isolated, SHOTa and SHOTb, which have identical...
متن کاملDifferential induction of four msx homeobox genes during fin development and regeneration in zebrafish.
To study the genetic regulation of growth control and pattern formation during fin development and regeneration, we have analysed the expression of four homeobox genes, msxA, msxB, msxC and msxD in zebrafish fins. The median fin fold, which gives rise to the unpaired fins, expresses these four msx genes during development. Transcripts of the genes are also present in cells of the presumptive pe...
متن کاملEpidermal dysplasia and abnormal hair follicles in transgenic mice overexpressing homeobox gene MSX-2.
The homeobox gene Msx-2 is expressed specifically in sites of skin appendage formation. To explore its part in skin morphogenesis, we produced transgenic mice expressing Msx-2 under the control of the cytomegalovirus promoter. The skin of these transgenic mice was flaky, exhibiting desquamation and shorter hairs. Histologic analysis showed thickened epidermis with hyperproliferation, which was ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2003
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7290185